Deep brain stimulation shows potential for Alzheimer’s patients over the age of 65

by • July 6, 2018 • Feature Slider, Feature-Home, Featured-Slides-HomeComments Off on Deep brain stimulation shows potential for Alzheimer’s patients over the age of 65109

New findings from Toronto Western Hospital’s (TW) Krembil Neuroscience Centre (KNC) suggests that Alzheimer’s participants over the age of 65 continue to derive the most benefit from deep brain stimulation of the fornix (DBS-f) according to their Phase II ADvance trial.

The research was published in the Journal of Alzheimer’s Disease, by a team of researchers led by Dr. Andres Lozano. The neurology and psychology aspects of the trial in Toronto were led by TW neurologist Dr. Peter Tang-wai and neuropsychologist Dr. Mary-Pat McAndrews respectively.

To further explore the benefits for this demographic, the research team plans to launch a Phase III, multi-centre international trial that will study the effects of DBS-f in 140 patients over the age of 65.

“We are encouraged by these findings as they continue to help us identify who will benefit most from DBS to treat Alzheimer’s disease and learn more about this illness,” says Dr. Andres Lozano, neurosurgeon and the principal investigator of the study. “With so few treatments available and the incidence of Alzheimer’s only expected to increase, we really need to fully explore all treatments that seem to be of benefit to patients.”

The first year of the ADvance trial was published in 2016. In that trial, forty-two patients with mild Alzheimer’s disease were enrolled in a randomized, double-blind multicentre phase II clinical trial and implanted with DBS electrodes directed at the fornix – a bundle of nerve fibres in the brain that carry signals from the hippocampus – and followed for a total of two years.

These latest results are from the second year of the trial in which the first 12 months measured the impact of electrical stimulation in the brain with patients randomly assigned to either the “on” or “off” stimulation group after their procedure and monitored. Once this phase of follow up was complete, all patients then had their electrodes turned on and were followed for another 12 months.

In the second 12-month phase, researchers noted similar observations they had seen in the first phase. Although there were no differences overall in cognitive outcomes between study participants who had their device turned on right after surgery and those who had it turned on after 12 months, those 65 years of age and older appeared to experience a slower progression of Alzheimer’s than those under that age, regardless of when their device was turned on.

“The next phase of our research will help determine whether this observed benefit is something we continue to see in this age group,” says Lozano who is also a university professor and chairman, Department of Neurosurgery, University of Toronto. “If it does, this could potentially give us a treatment for mild, late-onset Alzheimer’s disease.”

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