Design of the IGF-Trap was refined through collaborative work with NRC, whose protein engineering and production expertise delivered through its biologics program will continue to play an important role in the project.“Type I insulin-like growth factor receptor (IGF-1R) is recognized today as a validated anti-cancer target, but no satisfactory targeting agent has been developed to date,” says Elizabeth Douville, general partner at AmorChem. “Dr. Brodt’s technology will have clear advantages over existing strategies because it targets the ligands of the IGF-1R without binding insulin. Moreover, Dr. Brodt has generated very compelling data in animal models of lung, colon and breast cancer.”
The IGFs are involved in mammalian growth and development. IGF-1 is essential for many of the growth promoting effects of growth hormone and is involved in the development of normal breast tissue. IGF-1 has been implicated in breast carcinogenesis and was shown to be both anti-apoptotic and pro-mitogenic. It is expected that a decoy receptor (the IGF-Trap) would greatly impact the levels of bio available IGF-1 and IGF-2 at tumour sites, thereby blocking the ir proliferative/anti-apoptotic effects on the cancer cells.