Vancouver, BC-A world-renowned St. Paul’s Hospital lung researcher and Canada’s national Centre for Drug Research and Development (CDRD) have teamed up to fight one of the world’s deadliest lung illnesses – Chronic Obstructive Pulmonary Disease (COPD).
Dr. Don Sin, chest physician and leading lung researcher at Providence Health Care (PHC) and the Centre for Heart Lung Innovation (HLI) at St. Paul’s Hospital, has been working for the past 10 years to discover novel biomarkers that will lead to new therapies and improve the care of patients with COPD. Dr. Sin and his research group have made breakthrough discoveries that have shed light on why some individuals develop COPD and others do not. They are now in position to identify which of these discoveries will translate into drug targets.
CDRD’s Target Validation group, led by Dr. Edie Dullaghan, has partnered with Dr. Sin to advance his research from the lab into targeted drug development, leading to innovative therapies for patients with COPD. Now a new nine month project is underway to validate and characterize a subset of specific genes related to the disease. CDRD will analyze human lung tissue samples from both COPD and non-COPD patients in a blinded study.
“With the “omics” revolution, we have an unprecedented opportunity at Providence Health Care to improve the lives of millions of patients with COPD across Canada by developing new (disruptive) treatments that will relieve breathlessness, reduce hospitalizations and massively cut down deaths related to lung failure,” says Dr. Sin, who is also a Canada Research Chair in COPD. “This partnership with CDRD will bring synergies to the organization by enabling us to translate genomics data to tangible products and therapeutics for our patients.”
“This project exemplifies CDRD as a partner of choice for world-renowned scientists providing the critical independent validation required to move their research along the drug development continuum,” remarks Karimah Es Sabar, president and CEO of CDRD. “We aim to add value to Dr. Sin’s research by helping advance his important discoveries through our drug development platform. We can then identify and prioritize the specific targets with the highest degree of therapeutic and commercial potential.The results of this work will form the basis for further targeted studies validating novel drug therapeutic targets.”